Product Name
Anoctamin-5 (Ano5), Recombinant Protein
Full Product Name
Recombinant Mouse Anoctamin-5 (Ano5) , partial
Product Gene Name
Ano5 recombinant protein
[Similar Products]
Product Synonym Gene Name
Ano5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q75UR0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Ano5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Ano5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001258808.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001271879.1
[Other Products]
UniProt Primary Accession #
Q75UR0
[Other Products]
UniProt Secondary Accession #
Q2VPA8; Q3V657; Q8CC04[Other Products]
UniProt Related Accession #
Q75UR0[Other Products]
Molecular Weight
99,908 Da
NCBI Official Full Name
anoctamin-5 isoform 2
NCBI Official Synonym Full Names
anoctamin 5
NCBI Official Symbol
Ano5??[Similar Products]
NCBI Official Synonym Symbols
Gdd1; Tmem16e; 9330162L24
??[Similar Products]
NCBI Protein Information
anoctamin-5
UniProt Protein Name
Anoctamin-5
UniProt Synonym Protein Names
Gnathodiaphyseal dysplasia 1 protein homolog; Transmembrane protein 16E
UniProt Gene Name
Ano5??[Similar Products]
UniProt Synonym Gene Names
Gdd1; Tmem16e??[Similar Products]
NCBI Summary for Ano5
This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for Ano5
Does not exhibit calcium-activated chloride channel (CaCC) activity.
Research Articles on Ano5
1. Here we show that Ano5-deficient mice have reduced capacity to repair the sarcolemma following laser-induced damage, exhibit delayed regeneration after cardiotoxin injury and suffer from defective myoblast fusion necessary for the proper repair and regeneration of multinucleated myotubes. these data suggest that ANO5 plays an important role in sarcolemmal membrane dynamics.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
