Full Product Name
APOE Antibody
Product Synonym Names
AD2; Apo-E; APOE; Apolipoprotein E; apolipoprotein E3; LDLCQ5; LPG; MGC1571
Product Gene Name
anti-APOE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02649
Species Reactivity
Human, Mouse, Rat
Specificity
APOE antibody detects endogenous levels of total APOE protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human APOE.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-APOE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-APOE antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-APOE antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-APOE antibody
WB: 1:500~1:3000
ELISA: 1:10000
Testing Data of anti-APOE antibody
NCBI/Uniprot data below describe general gene information for APOE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000032.1
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NCBI GenBank Nucleotide #
NM_000041.3
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UniProt Primary Accession #
P02649
[Other Products]
UniProt Secondary Accession #
Q9P2S4; B2RC15; C0JYY5[Other Products]
UniProt Related Accession #
P02649[Other Products]
Molecular Weight
36,154 Da
NCBI Official Full Name
apolipoprotein E isoform b
NCBI Official Synonym Full Names
apolipoprotein E
NCBI Official Symbol
APOE??[Similar Products]
NCBI Official Synonym Symbols
AD2; LPG; APO-E; ApoE4; LDLCQ5
??[Similar Products]
NCBI Protein Information
apolipoprotein E
UniProt Protein Name
Apolipoprotein E
Protein Family
Apolipoprotein
UniProt Gene Name
APOE??[Similar Products]
UniProt Synonym Gene Names
Apo-E??[Similar Products]
NCBI Summary for APOE
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
UniProt Comments for APOE
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Product References and Citations for anti-APOE antibody
Zannis V.I., J. Biol. Chem. 259:5495-5499(1984). McLean J.W., J. Biol. Chem. 259:6498-6504(1984). Paik Y.-K., Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Research Articles on APOE
1. APOE rs405509-epsilon2/epsilon3/epsilon4 haplotypes modulate the risk of concussion susceptibility
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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