For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to human ApoE.

Affinity purified

1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Small volumes of anti-ApoE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Apolipoprotein-E (apoE) is a protein component of plasma lipoproteins. Three common ApoE alleles have been identified: ApoE2, ApoE3, and ApoE4. The corresponding three major isoforms, E2, E3, and E4, are recognized according to their relative position after isoelectric focusing. ApoE mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (Apo B/E) receptor and for the specific Apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Western Blot (WB)

WB: 1:1,000

Western blot analysis on human liver using anti-ApoE polyclonalantibody.

36kDa

apolipoprotein E

apolipoprotein E

Apolipoprotein E

Apo-E??[Similar Products]

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

1.?"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004). 2.?"Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site."Shuvaev V.V., Fujii J., Kawasaki Y., Itoh H., Hamaoka R., Barbier A., Ziegler O., Siest G., Taniguchi N.Biochim. Biophys. Acta 1454:296-308(1999).

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