Anti-SCAD / ACADS Antibody IHC-plus; ACADS; ACAD3; Butyryl-CoA dehydrogenase; SCAD; Unsaturated acyl-CoA reductase; Human SCAD; ACADS

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human ACADS. Predicted cross-reactivity based on amino acid sequence homology: mouse (84%), rat (84%), bovine (84%), pig (83%).

Immunoaffinity Purified

PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Small volumes of anti-SCAD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The nuclear ACADS gene encodes a mitochondrially-targeted protein product. Acyl-Coenzyme A dehydrogenase, short-chain specific, catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Clinical phenotypes, described elsewhere, are associated with ACADS hereditary deficiency.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (10 ug/ml), WB (1:500 - 1:3000)

Anti-ACADS antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Sample(30 g of whole cell lysate). A: MOLT4. 12% SDS PAGE. ACADS antibody diluted at 1:500.

44,297 Da

acyl-CoA dehydrogenase, C-2 to C-3 short chain

short-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase; unsaturated acyl-CoA reductase; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; mitochondrial short-chain specific acyl-CoA dehydrogenase

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

SCAD??[Similar Products]

ACADS_HUMAN

This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]

ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in *****s. Belongs to the acyl-CoA dehydrogenase family.

Protein type: EC 1.3.8.1; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding

Biological Process: response to starvation; fatty acid beta-oxidation; response to glucocorticoid stimulus; cellular lipid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; protein homotetramerization; butyrate catabolic process

Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of

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