Short-chain specific acyl-CoA dehydrogenase; Butyryl-CoA dehydrogenase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purified

100 ug (0.5 mg/ml) affinity purified rabbit anti-ACADS polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Appearance: Colorless liquid

0.5 mg/ml (lot specific)

At -20 degree C
Shelf Life: 12 months

Small volumes of anti-ACADS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background: ACADS (acyl-Coenzyme A dehydrogenase), is a homotetrameric mitochondrial flavoprotein that belongs to the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutation of this gene causes SCAD deficiency an acute acidosis and muscle weakness in infants and lipid-storage myopathy in *****s.

Diabetes, Obesity & Metabolic Syndrome; Lipid Metabolism; AntibodiesAntibodies & Supporting Tools; Primary Antibodies (A-Z)

Western Blot (WB)

Western Blot analysis (1-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.

44,765 Da

acyl-CoA dehydrogenase, C-2 to C-3 short chain

short-chain specific acyl-CoA dehydrogenase, mitochondrial

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

SCAD??[Similar Products]

ACADS_RAT

ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in *****s. Belongs to the acyl-CoA dehydrogenase family.

Protein type: Lipid-binding; Mitochondrial; Oxidoreductase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.3.8.1; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - butanoate

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding

Biological Process: response to starvation; fatty acid beta-oxidation; response to glucocorticoid stimulus; fatty acid beta-oxidation using acyl-CoA dehydrogenase; butyrate catabolic process; protein homotetramerization

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