Variable charge X-linked protein 1; Variable charge protein on X with ten repeats; VCX-10r; Variably charged protein X-B1; VCX-B1; VCX; VCX1; VCX10R; VCXB1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This VCX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human VCX1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-VCX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene belongs to the VCX/Y gene family, which has
multiple members on both X and Y chromosomes, and all are expressed
exclusively in male germ cells. The X-linked members are clustered
on chromosome Xp22 and Y-linked members are two identical copies of
the gene within a palindromic region on Yq11. The family members
share a high degree of sequence identity, with the exception that a
30-bp unit is tandemly repeated in X-linked members but occurs only
once in Y-linked members. The VCX gene cluster is polymorphic in
terms of copy number; different individuals may have a different
number of VCX genes. VCX/Y genes encode small and highly charged
proteins of unknown function. The presence of a putative bipartite
nuclear localization signal suggests that VCX/Y members are nuclear
proteins. This gene contains 10 repeats of the 30-bp unit.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

IHC~~1:50~100
WB~~1:1000

VCX1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the VCX1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

VCX1/VCX2/VCX3 Antibody (N-term) western blot analysis in A2058,MCF-7,MDA-MB453 cell line lysates (35ug/lane).This demonstrates the VCX1/VCX2/VCX3 antibody detected the VCX1/VCX2/VCX3 protein (arrow).

22289

variable charge, X-linked

variable charge X-linked protein 1

Variable charge X-linked protein 1

VCX1; VCX10R; VCXB1; VCX-10r; VCX-B1??[Similar Products]

VCX1_HUMAN

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

VCX: May mediate a process in spermatogenesis or may play a role in sex ratio distortion. Belongs to the VCX/VCY family.

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: nucleolus; nucleus

Molecular Function: chromatin binding

Biological Process: establishment and/or maintenance of chromatin architecture; ribosome assembly; spermatogenesis

Hansen, M.A., et al. Mol. Reprod. Dev. 75(2):219-229(2008)
Sy, S.M., et al. Lung Cancer 41(1):91-99(2003)
Zou, S.W., et al. Cell Res. 13(3):171-177(2003)
Fukami, M., et al. Am. J. Hum. Genet. 67(3):563-573(2000)
Lahn, B.T., et al. Hum. Mol. Genet. 9(2):311-319(2000)

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