Product Name
DHCR24, cDNA Clone
Full Product Name
DHCR24 cDNA Clone
Product Gene Name
DHCR24 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagcccg ccgtgtcgct ggccgtgtgc gcgctgctct tcctgctgtg ggtgcgcctg aaggggctgg agttcgtgct catccaccag cgctgggtgt tcgtgtgcct cttcctcctg ccgctctcgc ttatcttcga tatctactac tacgtgcgcg cctgggtggt gttcaagctc agcagcgctc cgcgcctgca cgagcagcgc gtgcgggaca tccagaagca ggtgcgggaa tggaaggagc agggtagcaa gaccttcatg tgcacggggc gccctggctg gctcactgtc tcactacgtg tcgggaagta caagaagaca cacaaaaaca tcatgatcaa cctgatggac attctggaag tggacaccaa gaaacagatt gtccgtgtgg agcccttggt gaccatgggc caggtgactg ccctgctgac ctccattggc tggactctcc ccgtgttgcc tgagcttgat gacctcacag tggggggctt gatcatgggc acaggcatcg agtcatcatc ccacaagtac ggcctgttcc aacacatctg cactgcttac gagctggtcc tggctgatgg cagctttgtg cgatgcactc cgtccgaaaa ctcagacctg ttctatgccg taccctggtc ctgtgggacg ctgggtttcc tggtggccgc tgagatccgc atcatccctg ccaagaagta cgtcaagctg cgtttcgagc cagtgcgggg cctggaggct atctgtgcca agttcaccca cgagtcccag cggcaggaga accacttcgt ggaagggctg ctctactccc tggatgaggc tgtcattatg acaggggtca tgacagatga ggcagagccc agcaagctga atagcattgg caattactac aagccgtggt tctttaagca tgtggagaac tatctgaaga caaaccgaga gggcctggag tacattccct tgagacacta ctaccaccgc cacacgcgca gcatcttctg ggagctccag gacattatcc cctttggcaa caaccccatc ttccgctacc tctttggctg gatggtgcct cccaagatct ccctcctgaa gctgacccag ggtgagaccc tgcgcaagct gtacgagcag caccacgtgg tgcaggacat gctggtgccc atgaagtgcc tgcagcaggc cctgcacacc ttccaaaacg acatccacgt ctaccccatc tggctgtgtc cgttcatcct gcccagccag ccaggcctag tgcaccccaa aggaaatgag gcagagctct acatcgacat tggagcatat ggggagccgc gtgtgaaaca ctttgaagcc aggtcctgca tgaggcagct ggagaagttt gtccgcagcg tgcatggctt ccagatgctg tatgccgact gctacatgaa ccgggaggag ttctgggaga tgtttgatgg ctccttgtac cacaagctgc gagagaagct gggttgccag gacgccttcc ccgaggtgta cgacaagatc tgcaaggccg ccaggcactg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DHCR24 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DHCR24. It may not necessarily be applicable to this product.
NCBI Accession #
BC004375
[Other Products]
UniProt Secondary Accession #
Q9HBA8; B7Z817; D3DQ51[Other Products]
UniProt Related Accession #
Q15392[Other Products]
Molecular Weight
54,750 Da
NCBI Official Full Name
Homo sapiens 24-dehydrocholesterol reductase, mRNA
NCBI Official Synonym Full Names
24-dehydrocholesterol reductase
NCBI Official Symbol
DHCR24??[Similar Products]
NCBI Official Synonym Symbols
DCE; SELADIN1; Nbla03646; seladin-1
??[Similar Products]
NCBI Protein Information
delta(24)-sterol reductase
UniProt Protein Name
Delta(24)-sterol reductase
UniProt Synonym Protein Names
24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1
Protein Family
Delta(24)-sterol reductase
UniProt Gene Name
DHCR24??[Similar Products]
UniProt Synonym Gene Names
KIAA0018??[Similar Products]
UniProt Entry Name
DHC24_HUMAN
NCBI Summary for DHCR24
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
UniProt Comments for DHCR24
Diminuto: the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth.
Protein type: Oxidoreductase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; EC 1.3.1.72
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleus
Molecular Function: delta24(24-1) sterol reductase activity; delta24-sterol reductase activity; enzyme binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; peptide antigen binding
Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol; cholesterol biosynthetic process via lathosterol; negative regulation of apoptosis; negative regulation of caspase activity; response to oxidative stress; skin development; tissue development
Disease: Desmosterolosis
Research Articles on DHCR24
1. DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP-negative hepatocellular carcinoma.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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