Full Product Name
CABP4 antibody - N-terminal region
Product Gene Name
anti-CABP4 antibody
[Similar Products]
Product Synonym Gene Name
CSNB2B[Similar Products]
Antibody/Peptide Pairs
CABP4 peptide (MBS3239454) is used for blocking the activity of CABP4 antibody (MBS3214517)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: VVTPKSDAEE PPLTRKRSKK ERGLRGSRKR TGSSGEQTGP EAPGSSNNPP
3D Structure
ModBase 3D Structure for P57796
Species Reactivity
Horse, Human
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Horse: 86%; Human: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human CABP4
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CABP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CABP4 antibody
This is a rabbit polyclonal antibody against CABP4. It was validated on Western Blot
Target Description: This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B.
Product Categories/Family for anti-CABP4 antibody
Polyclonal; Neuroscience; Stem Cells; Various; Cell Morphogenesis;
Applications Tested/Suitable for anti-CABP4 antibody
Western Blot (WB)
Western Blot (WB) of anti-CABP4 antibody
WB Suggested Anti-CABP4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain
NCBI/Uniprot data below describe general gene information for CABP4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_660201
[Other Products]
NCBI GenBank Nucleotide #
NM_145200
[Other Products]
UniProt Primary Accession #
P57796
[Other Products]
UniProt Related Accession #
P57796[Other Products]
NCBI Official Full Name
calcium-binding protein 4 isoform a
NCBI Official Synonym Full Names
calcium binding protein 4
NCBI Official Symbol
CABP4??[Similar Products]
NCBI Official Synonym Symbols
CRSD; CSNB2B
??[Similar Products]
NCBI Protein Information
calcium-binding protein 4
UniProt Protein Name
Calcium-binding protein 4
Protein Family
Calcium-binding protein
UniProt Gene Name
CABP4??[Similar Products]
UniProt Synonym Gene Names
CaBP4??[Similar Products]
UniProt Entry Name
CABP4_HUMAN
NCBI Summary for CABP4
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for CABP4
Function: Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages
By similarity.
Subunit structure: Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner
By similarity. Interacts (via N-terminus) with UNC119
By similarity.
Subcellular location: Cytoplasm. Note: Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors
By similarity. Ref.5
Tissue specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea.
Post-translational modification: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity
By similarity.
Involvement in disease: Night blindness, congenital stationary, 2B (CSNB2B) [MIM:610427]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities: Contains 4 EF-hand domains.
Research Articles on CABP4
1. CABP4-related retinal disease is a cone-rod system disorder with possible foveal abnormalities.
Precautions
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Disclaimer
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