Full Product Name
CABP4 Antibody
Product Gene Name
anti-CABP4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P57796
Species Reactivity
Human, Mouse
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-CABP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CABP4 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CABP4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001287824.1
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NCBI GenBank Nucleotide #
NM_001300895.1
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UniProt Primary Accession #
P57796
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UniProt Secondary Accession #
Q8N4Z2; Q8WWY5[Other Products]
UniProt Related Accession #
P57796[Other Products]
Molecular Weight
19,600 Da
NCBI Official Full Name
calcium-binding protein 4 isoform b
NCBI Official Synonym Full Names
calcium binding protein 4
NCBI Official Symbol
CABP4??[Similar Products]
NCBI Official Synonym Symbols
CRSD; CSNB2B
??[Similar Products]
NCBI Protein Information
calcium-binding protein 4
UniProt Protein Name
Calcium-binding protein 4
Protein Family
Calcium-binding protein
UniProt Gene Name
CABP4??[Similar Products]
UniProt Synonym Gene Names
CaBP4??[Similar Products]
NCBI Summary for CABP4
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for CABP4
CABP4: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytosol; synapse; terminal button
Molecular Function: calcium ion binding
Biological Process: visual perception
Disease: Night Blindness, Congenital Stationary, Type 2b
Research Articles on CABP4
1. we found a homozygous compound mutation in the CABP4 gene in 3 patients with congenital stationary night blindess 2.
Precautions
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Disclaimer
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