AW060387; Ca(V) beta 2; CAB2; CAVB2; Cavbeta2; Cchb2; Lambert Eaton Myasthenic syndrome antigen; MYSB antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

0.6 ug/ul in antibody stabilization buffer (lot specific)

-20? degree C for long term storage

Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Affinity Purified Voltage dependent L-type calcium channel subunit beta-2 Antibody
The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.

Primary Antibodies; Neuroscience; Neurotransmission; CACNB2 Antibody

ELISA (EIA), IMM, Western Blot (WB)

Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

68,066 Da

calcium voltage-gated channel auxiliary subunit beta 2

voltage-dependent L-type calcium channel subunit beta-2

Voltage-dependent L-type calcium channel subunit beta-2

Cacnlb2; CAB2??[Similar Products]

CACB2_RAT

auxillary subunit of the L-type Ca(2+) channel [RGD, Feb 2006]

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: sarcolemma; voltage-gated calcium channel complex

Molecular Function: actin filament binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: calcium ion transport; neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception

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