Full Product Name
CABP4 (Calcium-binding Protein 4, CaBP4)
Product Synonym Names
Anti -CABP4 (Calcium-binding Protein 4, CaBP4)
Product Gene Name
anti-CABP4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MTEPWLALGT SWTLPLQDRE LGPEELDELQ AAFEEFDTDR DGYISHRELG DCMRTLGYMP TEMELLEVSQ HIKMRMGGRV DFEEFVELIG PKLREETAHM LGVRELRIAF REFDRDRDGR ITVAELREAV PALLGEPLAG PELDEMLREV DLNGDGTVDF DEFVMMLSRH
Chromosome Location
Chromosome: 11; NC_000011.9 (67219886..67229245). Location: 11q13.2
3D Structure
ModBase 3D Structure for P57796
Specificity
Recognizes human CABP4.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length recombinant corresponding to aa1-171 from human CABP4 (AAH33167) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CABP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CABP4 antibody
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B.
Product Categories/Family for anti-CABP4 antibody
Antibodies; Abs to Calcium Binding Proteins
Applications Tested/Suitable for anti-CABP4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CABP4 antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for CABP4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_660201.1
[Other Products]
NCBI GenBank Nucleotide #
NM_145200.3
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UniProt Primary Accession #
P57796
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UniProt Secondary Accession #
Q8N4Z2; Q8WWY5[Other Products]
UniProt Related Accession #
P57796[Other Products]
Molecular Weight
30,433 Da[Similar Products]
NCBI Official Full Name
calcium-binding protein 4
NCBI Official Synonym Full Names
calcium binding protein 4
NCBI Official Symbol
CABP4??[Similar Products]
NCBI Official Synonym Symbols
CSNB2B
??[Similar Products]
NCBI Protein Information
calcium-binding protein 4
UniProt Protein Name
Calcium-binding protein 4
Protein Family
Calcium-binding protein
UniProt Gene Name
CABP4??[Similar Products]
UniProt Synonym Gene Names
CaBP4??[Similar Products]
UniProt Entry Name
CABP4_HUMAN
NCBI Summary for CABP4
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. [provided by RefSeq, Mar 2010]
UniProt Comments for CABP4
CABP4: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: extracellular region; terminal button; synapse; cytosol
Molecular Function: calcium ion binding
Biological Process: visual perception; retinal cone cell development; phototransduction; photoreceptor cell morphogenesis; signal transduction; retinal bipolar neuron differentiation
Disease: Night Blindness, Congenital Stationary, Type 2b
Research Articles on CABP4
1. Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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