For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of CABP4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a synthetic peptide designed for use in combination with anti-CABP4 Antibody, made

Target Description: This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B.

Peptide

Western Blot (WB)

30kDa

calcium binding protein 4

calcium-binding protein 4

Calcium-binding protein 4

CaBP4??[Similar Products]

CABP4_HUMAN

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Function: Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages

By similarity.

Subunit structure: Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner

By similarity. Interacts (via N-terminus) with UNC119

By similarity.

Subcellular location: Cytoplasm. Note: Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors

By similarity. Ref.5

Tissue specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea.

Post-translational modification: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity

By similarity.

Involvement in disease: Night blindness, congenital stationary, 2B (CSNB2B) [MIM:610427]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities: Contains 4 EF-hand domains.

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