Product Name
CACNB2, Blocking Peptide
Full Product Name
CACNB2 Immunizing Peptide
Product Synonym Names
CACNB2; calcium channel, voltage-dependent, beta 2 subunit; CACNLB2; CAVB2; FLJ23743; MYSB; CAB2; calcium channel voltage-dependent subunit beta 2; lambert-Eaton myasthenic syndrome antigen B; myasthenic (Lambert-Eaton) syndrome antigen B; voltage-depende; CACNB2 (aa565-579)
Product Gene Name
CACNB2 blocking peptide
[Similar Products]
CACNB2 peptide (MBS427647) is used for blocking the activity of CACNB2 antibody (MBS422636)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ECNKQRSRHK SKDRY
Species Reactivity
Human, Mouse, Rat, Dog, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CACNB2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CACNB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000715.2
[Other Products]
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1[Other Products]
NCBI GenBank Nucleotide #
NM_000724.3
[Other Products]
UniProt Secondary Accession #
O00304; Q5QJ99; Q5QJA0; Q5VVG9; Q5VVH0; Q5VWV6; Q6TME1; Q6TME2; A6PVM5; A6PVM7; A6PVM8[Other Products]
UniProt Related Accession #
Q08289; AAB27916[Other Products]
Molecular Weight
65,658 Da
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2 isoform 1
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit beta 2
NCBI Official Symbol
CACNB2??[Similar Products]
NCBI Official Synonym Symbols
MYSB; CAVB2; CACNLB2
??[Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
CACNB2??[Similar Products]
UniProt Synonym Gene Names
CACNLB2; MYSB; CAB2; MYSB??[Similar Products]
UniProt Entry Name
CACB2_HUMAN
NCBI Summary for CACNB2
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
UniProt Comments for CACNB2
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 10p12
Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated calcium channel complex
Molecular Function: actin filament binding; calcium channel activity; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity
Biological Process: neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception
Disease: Brugada Syndrome 4
Research Articles on CACNB2
1. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.
Precautions
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Disclaimer
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