Product Name
CACNB2, Polyclonal Antibody
Full Product Name
CACNB2 antibody - middle region
Product Gene Name
anti-CACNB2 antibody
[Similar Products]
Product Synonym Gene Name
RP11-383B4.2; CACNLB2; FLJ23743; MYSB; CAVB2[Similar Products]
Antibody/Peptide Pairs
CACNB2 peptide (MBS3227633) is used for blocking the activity of CACNB2 antibody (MBS3202654)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: ACEHLADYLE AYWKATHPPS SSLPNPLLSR TLATSSLPLS PTLASNSQGS
3D Structure
ModBase 3D Structure for Q5VWD7
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Protein A purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%; Zebrafish: 82%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CACNB2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNB2 antibody
This is a rabbit polyclonal antibody against CACNB2. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: CACNB2 is a subunit of voltage-dependent calcium (Ca2+) channels, expressed in the CNS. It appears to serve an obligatory function.
Product Categories/Family for anti-CACNB2 antibody
Polyclonal; Ion Channel;
Applications Tested/Suitable for anti-CACNB2 antibody
Western Blot (WB)
Western Blot (WB) of anti-CACNB2 antibody
WB Suggested Anti-CACNB2 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate
NCBI/Uniprot data below describe general gene information for CACNB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000715
[Other Products]
NCBI GenBank Nucleotide #
NM_000724
[Other Products]
UniProt Primary Accession #
Q5VWD7
[Other Products]
UniProt Related Accession #
Q08289[Other Products]
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2 isoform 1
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit beta 2
NCBI Official Symbol
CACNB2??[Similar Products]
NCBI Official Synonym Symbols
MYSB; CAVB2; CACNLB2
??[Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2
Protein Family
Voltage-dependent L-type calcium channel
NCBI Summary for CACNB2
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Research Articles on CACNB2
1. Data show that an indispensable beta-subunit of the voltage-gated Ca(2+) channel Cav1.2 interaction with H-Ras is independently of Ca(2+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK/CREB pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
