Product Name
ACADS, cDNA Clone
Full Product Name
ACADS cDNA Clone
Product Gene Name
ACADS cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccgccg cgctgctcgc ccgggcctcg ggccctgccc gcagagctct ctgtcctagg gcctggcggc agttacacac catctaccag tctgtggaac tgcccgagac acaccagatg ttgctccaga catgccggga ctttgccgag aaggagttgt ttcccattgc agcccaggtg gataaggaac atctcttccc agcggctcag gtgaagaaga tgggcgggct tgggcttctg gccatggacg tgcccgagga gcttggcggt gctggcctcg attacctggc ctacgccatc gccatggagg agatcagccg cggctgcgcc tccaccggag tcatcatgag tgtcaacaac tctctctacc tggggcccat cttgaagttt ggctccaagg agcagaagca ggcgtgggtc acgcctttca ccagtggtga caaaattggc tgctttgccc tcagcgaacc agggaacggc agtgatgcag gagctgcgtc caccaccgcc cgggccgagg gcgactcatg ggttctgaat ggaaccaaag cctggatcac caatgcctgg gaggcttcgg ctgccgtggt ctttgccagc acggacagag ccctgcaaaa caagagcatc agtgccttcc tggtccccat gccaacgcct gggctcacgt tggggaagaa agaagacaag ctgggcatcc ggggctcatc cacggccaac ctcatctttg aggactgtcg catccccaag gacagcatcc tgggggagcc agggatgggc ttcaagatag ccatgcaaac cctggacatg ggccgcatcg gcatcgcctc ccaggccctg ggcattgccc agaccgccct cgattgtgct gtgaactacg ctgagaatcg catggccttc ggggcgcccc tcaccaagct ccaggtcatc cagttcaagt tggcagacat ggccctggcc ctggagagtg cccggctgct gacctggcgt gctgccatgc tgaaggataa caagaagcct ttcatcaagg aggcagccat ggccaagctg gccgcctcgg aggccgcgac cgccatcagc caccaggcca tccagatcct gggcggcatg ggctacgtga cagagatgcc ggcagagcgg cactaccgcg acgcccgcat cactgagatc tacgagggca ccagcgaaat ccagcggctg gtgatcgccg ggcatctgct caggagctac cggagctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACADS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACADS. It may not necessarily be applicable to this product.
NCBI Accession #
BC025963
[Other Products]
UniProt Secondary Accession #
P78331[Other Products]
UniProt Related Accession #
P16219[Other Products]
Molecular Weight
44,297 Da
NCBI Official Full Name
Homo sapiens acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, mRNA
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-2 to C-3 short chain
NCBI Official Symbol
ACADS??[Similar Products]
NCBI Official Synonym Symbols
SCAD; ACAD3
??[Similar Products]
NCBI Protein Information
short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Butyryl-CoA dehydrogenase
Protein Family
Short-chain specific acyl-CoA dehydrogenase
UniProt Gene Name
ACADS??[Similar Products]
UniProt Synonym Gene Names
SCAD??[Similar Products]
UniProt Entry Name
ACADS_HUMAN
NCBI Summary for ACADS
This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for ACADS
ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in *****s. Belongs to the acyl-CoA dehydrogenase family.
Protein type: EC 1.3.8.1; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Oxidoreductase; Mitochondrial
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: mitochondrial matrix; mitochondrion; nucleus
Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; electron carrier activity; FAD binding
Biological Process: butyrate catabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis
Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of
Research Articles on ACADS
1. T in ACADS compared to controls and they belonged to various pathways, such as the antioxidant system and amino acid metabolism.">Thirteen proteins had significant alteration in protein levels in patients carrying variation c.319C>T in ACADS compared to controls and they belonged to various pathways, such as the antioxidant system and amino acid metabolism.
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Disclaimer
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