Toll-like receptor 3; CD283; TLR3

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgM

303CT19.9.2

Mouse

This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-TLR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a member of the
Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are
highly conserved from Drosophila to humans and share structural and
functional similarities. They recognize pathogen-associated
molecular patterns (PAMPs) that are expressed on infectious agents,
and mediate the production of cytokines necessary for the
development of effective immunity. The various TLRs exhibit
different patterns of expression. This receptor is most abundantly
expressed in placenta and pancreas, and is restricted to the
dendritic subpopulation of the leukocytes. It recognizes dsRNA
associated with viral infection, and induces the activation of
NF-kappaB and the production of type I interferons. It may thus
play a role in host defense against viruses. Use of alternative
polyadenylation sites to generate different length transcripts has
been noted for this gene.

Immunology; Microbiology; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:100~4000

TLR3 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TLR3 antibody detected the TLR3 protein (arrow).

103829

toll-like receptor 3

toll-like receptor 3

Toll-like receptor 3

TLR3_HUMAN

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; lysosomal membrane; cytoplasm; endosome membrane

Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity

Biological Process: negative regulation of osteoclast differentiation; I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; inflammatory response; defense response to virus; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; male gonad development; activation of NF-kappaB-inducing kinase; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; hyperosmotic response; positive regulation of chemokine biosynthetic process; detection of virus; positive regulation of interferon-beta biosynthetic process; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response; positive regulation of inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Perez de Diego, R., et al. Immunity 33(3):400-411(2010)
Zhou, Y., et al. Immunology 131(1):40-49(2010)
Perrot, I., et al. J. Immunol. 185(4):2080-2088(2010)
Paone, A., et al. Neoplasia 12(7):539-549(2010)

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