Full Product Name
Anti-HYAL1 antibody
Product Synonym Names
Hyaluronidase-1; hyaluronoglucosaminidase 1; HYAL 1 antibody; Hyal-1 antibody; HYAL1 antibody; HYAL1_HUMAN antibody; Hyaluronidase 1 antibody; Hyaluronidase-1 antibody; Hyaluronoglucosaminidase 1 antibody; Hyaluronoglucosaminidase-1 antibody; Hyaluronoglucosaminidase1 antibody; LUCA 1 antibody; LUCA-1 antibody; LUCA1 antibody; Lung carcinoma protein 1 antibody; MGC45987 antibody; NAT6 antibody; Plasma hyaluronidase antibody; Tumor suppressor LUCA 1 antibody
Product Gene Name
anti-HYAL1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q91ZJ9
Purity/Purification
Immunogen affinity purified.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1 (434-450aa LKDRAQMAMKFRCRCYR), different from the related rat sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HYAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HYAL1 antibody
Description: Rabbit IgG polyclonal antibody for Hyaluronidase-1(HYAL1) detection. Tested with WB in mouse.
Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
Applications Tested/Suitable for anti-HYAL1 antibody
Western Blot (WB)
Western Blot (WB) of anti-HYAL1 antibody
Anti-HYAL1 antibody, MBS177085, Western blotting
Lane 1: NRK Cell Lysate
Lane 2: Mouse Liver Tissue Lysate
Lane 3: Mouse Kidney Tissue Lysate
Lane 4: SP2/0 Cell Lysate
NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.
NCBI Accession #
Q91ZJ9.3
[Other Products]
UniProt Primary Accession #
Q91ZJ9
[Other Products]
UniProt Secondary Accession #
O70229; Q8CE62; Q8QZX3; Q8VBW7; Q8VDK0; B1AV90[Other Products]
UniProt Related Accession #
Q91ZJ9[Other Products]
Molecular Weight
51,436 Da
NCBI Official Full Name
Hyaluronidase-1
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 1
NCBI Official Symbol
Hyal1??[Similar Products]
NCBI Official Synonym Symbols
Hya1; Hyal-1
??[Similar Products]
NCBI Protein Information
hyaluronidase-1; hyaluronidase 1; hyaluronoglucosaminidase-1
UniProt Protein Name
Hyaluronidase-1
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-1
UniProt Gene Name
Hyal1??[Similar Products]
UniProt Synonym Gene Names
Hyal-1??[Similar Products]
UniProt Entry Name
HYAL1_MOUSE
UniProt Comments for HYAL1
HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Secreted, signal peptide; EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted
Cellular Component: extracellular space; lysosome; cytoplasm; extracellular region; cytoplasmic vesicle
Molecular Function: viral receptor activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hyaluronan synthase activity; transcription factor binding; catalytic activity; hyalurononglucosaminidase activity
Biological Process: positive regulation of cell adhesion; metabolic process; response to virus; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; response to reactive oxygen species; positive regulation of angiogenesis; hyaluronan biosynthetic process; carbohydrate metabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation
Research Articles on HYAL1
1. The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.
Precautions
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Disclaimer
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