Full Product Name
POLR1C Antibody
Product Synonym Names
DNA-directed RNA polymerase I 40 kDa polypeptide; POLR1C; POLR1E; RPA39; RPA5; RPAC1
Product Gene Name
anti-POLR1C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15160
Species Reactivity
Human, Mouse
Specificity
POLR1C Antibody detects endogenous levels of total POLR1C
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-POLR1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-POLR1C antibody
Western Blot (WB)
Application Notes for anti-POLR1C antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-POLR1C antibody
Western blot analysis of extracts from A549 cells, using POLR1C antibody.
NCBI/Uniprot data below describe general gene information for POLR1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001305805.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001318876.1
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UniProt Primary Accession #
O15160
[Other Products]
UniProt Secondary Accession #
O75395; Q5JTE3[Other Products]
UniProt Related Accession #
O15160[Other Products]
NCBI Official Full Name
DNA-directed RNA polymerases I and III subunit RPAC1 isoform 2
NCBI Official Synonym Full Names
RNA polymerase I and III subunit C
NCBI Official Symbol
POLR1C??[Similar Products]
NCBI Official Synonym Symbols
AC40; RPA5; TCS3; HLD11; RPA39; RPA40; RPAC1; RPC40
??[Similar Products]
NCBI Protein Information
DNA-directed RNA polymerases I and III subunit RPAC1
UniProt Protein Name
DNA-directed RNA polymerases I and III subunit RPAC1
UniProt Synonym Protein Names
AC40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RPA40; RPA39; RPC40
Protein Family
DNA-directed RNA polymerases
UniProt Gene Name
POLR1C??[Similar Products]
UniProt Synonym Gene Names
POLR1E; DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; RPA40??[Similar Products]
NCBI Summary for POLR1C
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for POLR1C
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft ().
Research Articles on POLR1C
1. Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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