Full Product Name
POLR1C Antibody
Product Synonym Names
DNA-directed RNA polymerase I 40 kDa polypeptide; POLR1C; POLR1E; RPA39; RPA5; RPAC1
Product Gene Name
anti-POLR1C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15160
Species Reactivity
Human, Mouse
Specificity
POLR1C antibody detects endogenous levels of total POLR1C protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human POLR1C.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-POLR1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-POLR1C antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-POLR1C antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-POLR1C antibody
WB: 1:500~1:1000
ELISA: 1:40000
Western Blot (WB) of anti-POLR1C antibody
Western blot analysis of extracts from A549 cells, using POLR1C antibody.
NCBI/Uniprot data below describe general gene information for POLR1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001305805.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001318876.1
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UniProt Primary Accession #
O15160
[Other Products]
UniProt Secondary Accession #
O75395; Q5JTE3[Other Products]
UniProt Related Accession #
O15160[Other Products]
Molecular Weight
38,647 Da
NCBI Official Full Name
DNA-directed RNA polymerases I and III subunit RPAC1 isoform 2
NCBI Official Synonym Full Names
RNA polymerase I and III subunit C
NCBI Official Symbol
POLR1C??[Similar Products]
NCBI Official Synonym Symbols
AC40; RPA5; TCS3; HLD11; RPA39; RPA40; RPAC1; RPC40
??[Similar Products]
NCBI Protein Information
DNA-directed RNA polymerases I and III subunit RPAC1
UniProt Protein Name
DNA-directed RNA polymerases I and III subunit RPAC1
UniProt Synonym Protein Names
AC40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RPA40; RPA39; RPC40
Protein Family
DNA-directed RNA polymerases
UniProt Gene Name
POLR1C??[Similar Products]
UniProt Synonym Gene Names
POLR1E; DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; RPA40??[Similar Products]
NCBI Summary for POLR1C
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for POLR1C
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft ().
Product References and Citations for anti-POLR1C antibody
Dammann R., Biochim. Biophys. Acta 1396:153-157(1998). Mao M., Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998). Mungall A.J., Nature 425:805-811(2003).
Research Articles on POLR1C
1. Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome.
Precautions
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Disclaimer
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