Product Name
HYAL1, Blocking Peptide
Full Product Name
HYAL1 Antibody (C-term) Blocking Peptide
Product Synonym Names
Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1
Product Gene Name
HYAL1 blocking peptide
[Similar Products]
Product Synonym Gene Name
LUCA1[Similar Products]
Antibody/Peptide Pairs
HYAL1 peptide (MBS9221198) is used for blocking the activity of HYAL1 antibody (MBS9203612)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q12794
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted. Lysosome
Tissue Location
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in ***** brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of HYAL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HYAL1 blocking peptide
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.
NCBI Accession #
Q12794.2
[Other Products]
UniProt Primary Accession #
Q12794
[Other Products]
UniProt Secondary Accession #
Q6FH23; Q6PIZ6; Q7KYU2; Q7LE34; Q8NFK5; Q8NFK6; Q8NFK7; Q8NFK8; Q8NFK9; Q93013; Q9UKD5[Other Products]
UniProt Related Accession #
Q12794[Other Products]
Molecular Weight
37,439 Da
NCBI Official Full Name
Hyaluronidase-1
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 1
NCBI Official Symbol
HYAL1??[Similar Products]
NCBI Official Synonym Symbols
MPS9; NAT6; LUCA1; HYAL-1
??[Similar Products]
NCBI Protein Information
hyaluronidase-1
UniProt Protein Name
Hyaluronidase-1
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
UniProt Gene Name
HYAL1??[Similar Products]
UniProt Synonym Gene Names
LUCA1; Hyal-1; LuCa-1??[Similar Products]
UniProt Entry Name
HYAL1_HUMAN
NCBI Summary for HYAL1
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HYAL1
HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted, signal peptide; EC 3.2.1.35
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; lysosomal lumen; lysosome
Molecular Function: hyaluronan synthase activity; hyalurononglucosaminidase activity; transcription factor binding; viral receptor activity
Biological Process: cartilage development; chondroitin sulfate catabolic process; hyaluronan biosynthetic process; hyaluronan catabolic process; hyaluronan metabolic process; inflammatory response; negative regulation of cell growth; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of growth; response to antibiotic; response to reactive oxygen species; response to virus
Disease: Mucopolysaccharidosis, Type Ix
Research Articles on HYAL1
1. The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR-210, miR-96, lncRNA-UCA1, 91.5 and ).
Precautions
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Disclaimer
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