Full Product Name
HYAL1 Antibody
Product Gene Name
anti-HYAL1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Form/Format
Purified by peptide affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.
Other Notes
Small volumes of anti-HYAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HYAL1 antibody
Rabbit polyclonal HYAL1 (1) antibody was raised against a 15 amino acid peptide from the intermediate residues of human HYAL1.
Product Categories/Family for anti-HYAL1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-HYAL1 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HYAL1 antibody
Peptide ELISA: 1:5,000-1:20,000
WB: 1:200-500
IHC: 1:50-500
Testing Data of anti-HYAL1 antibody
NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_009296.1
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NCBI GenBank Nucleotide #
NM_007312.3
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UniProt Secondary Accession #
Q6FH23; Q6PIZ6; Q7KYU2; Q7LE34; Q8NFK5; Q8NFK6; Q8NFK7; Q8NFK8; Q8NFK9; Q93013; Q9UKD5[Other Products]
UniProt Related Accession #
Q12794[Other Products]
Molecular Weight
37,439 Da
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 1
NCBI Official Symbol
HYAL1??[Similar Products]
NCBI Official Synonym Symbols
MPS9; NAT6; LUCA1; HYAL-1
??[Similar Products]
NCBI Protein Information
hyaluronidase-1
UniProt Protein Name
Hyaluronidase-1
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
UniProt Gene Name
HYAL1??[Similar Products]
UniProt Synonym Gene Names
LUCA1; Hyal-1; LuCa-1??[Similar Products]
NCBI Summary for HYAL1
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HYAL1
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Product References and Citations for anti-HYAL1 antibody
(1) Deschrevel, B., Lenormand, H., et al.Hyaluronidase activity is modulated by complexing with various polyelectrolytes including hyaluronan.Matrix Biol. 2008; 27 (3):242-253.
Research Articles on HYAL1
1. Data revealed a significant inverse correlation between ERalpha and HYAL1 gene expression in human breast tumors. HYAL1 was found repressed by estrogen through ERalpha binding to a consensus response element (ERE) located in the proximal promoter of HYAL1 and flanked by an Sp1 , required to achieve optimal estrogen repression.
Precautions
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Disclaimer
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