Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous level of total HYAL1 polyclonal antibody.

Antigen Affinity Purified

PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-HYAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:20 - 1:200

Immunohistochemical analysis of paraffin-embedded human endommetrial cancer using at dilution of 1:100.

Immunohistochemical analysis of paraffin-embedded human liver using at dilution of 1:100.

37,439 Da

hyaluronoglucosaminidase 1

hyaluronidase-1

Hyaluronidase-1

LUCA1; Hyal-1; LuCa-1??[Similar Products]

HYAL1_HUMAN

HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; lysosomal lumen; lysosome

Molecular Function: hyaluronan synthase activity; hyalurononglucosaminidase activity; transcription factor binding; viral receptor activity

Biological Process: cartilage development; chondroitin sulfate catabolic process; hyaluronan biosynthetic process; hyaluronan catabolic process; hyaluronan metabolic process; inflammatory response; negative regulation of cell growth; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of growth; response to antibiotic; response to reactive oxygen species; response to virus

Disease: Mucopolysaccharidosis, Type Ix

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