Full Product Name
Monoclonal Antibody to TLR3 (Clone: ABM15D5)-PE conjugated
Product Synonym Names
TLR3; CD283
Product Gene Name
anti-TLR3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15455
Purity/Purification
Purified
Protein G Chromatography
Form/Format
0.04mg/ml in PBS with 0.05% Azide.
Immunogen Information
A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
Other Notes
Small volumes of anti-TLR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLR3 antibody
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
Product Categories/Family for anti-TLR3 antibody
TLR and Innate Immunity
Applications Tested/Suitable for anti-TLR3 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-TLR3 antibody
FC/FACS analysis: 0.5-1 ug/10^6 cells
Flow Cytometry (FC/FACS) of anti-TLR3 antibody
Fig-1: Intracellular flow analysis of TLR3 PE conjugated in human PBMC (lymphocytes) using 0.5 ug/10^6 cells of TLR3 PE conjugated antibody (Clone: ABM15D5). Green represents isotype control; red represents anti-TLR3 PE conjugated antibody.
NCBI/Uniprot data below describe general gene information for TLR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003256.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003265.2
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UniProt Primary Accession #
O15455
[Other Products]
UniProt Secondary Accession #
Q4VAL2; Q504W0; B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4[Other Products]
UniProt Related Accession #
O15455[Other Products]
Molecular Weight
72,937 Da
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll like receptor 3
NCBI Official Symbol
TLR3??[Similar Products]
NCBI Official Synonym Symbols
CD283; IIAE2
??[Similar Products]
NCBI Protein Information
toll-like receptor 3
UniProt Protein Name
Toll-like receptor 3
UniProt Synonym Protein Names
CD_antigen: CD283
Protein Family
Toll-like receptor
UniProt Gene Name
TLR3??[Similar Products]
NCBI Summary for TLR3
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TLR3
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Research Articles on TLR3
1. we report that autophagy is associated with apoptosis processes, involving LC3 and TRIF-colocation in human HCC cells. Regulation of autophagy and the TLR3-TRIF pathway may be effective in the treatment of liver cancer.
Precautions
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Disclaimer
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