Full Product Name
DARS2 Polyclonal Antibody
Product Synonym Names
LBSL; ASPRS; MT-ASPRS
Product Gene Name
anti-DARS2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AL109921 Genomic DNA
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human DARS2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74707 / sc-74708 / sc-98541
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DARS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DARS2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DARS2 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Western Blot (WB) of anti-DARS2 antibody
Western blot analysis of extracts of various cells, using DARS2 antibody.
Immunohistochemistry (IHC) of anti-DARS2 antibody
Immunohistochemistry of paraffin-embedded human liver injury using DARS2 antibody at dilution of1:100 (x40 lens).
Immunohistochemistry (IHC) of anti-DARS2 antibody
Immunohistochemistry of paraffin-embedded human gastric using DARS2 antibody at dilution of1:100 (x40 lens).
NCBI/Uniprot data below describe general gene information for DARS2. It may not necessarily be applicable to this product.
UniProt Related Accession #
Q6PI48[Other Products]
NCBI Official Full Name
DARS2 protein
NCBI Official Synonym Full Names
aspartyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
DARS2??[Similar Products]
NCBI Official Synonym Symbols
LBSL; ASPRS; MT-ASPRS
??[Similar Products]
NCBI Protein Information
aspartate--tRNA ligase, mitochondrial
UniProt Protein Name
Aspartate--tRNA ligase, mitochondrial
UniProt Synonym Protein Names
Aspartyl-tRNA synthetase; AspRS
UniProt Gene Name
DARS2??[Similar Products]
UniProt Synonym Gene Names
AspRS??[Similar Products]
UniProt Entry Name
SYDM_HUMAN
NCBI Summary for DARS2
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
UniProt Comments for DARS2
DARS2: Defects in DARS2 are a cause of leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). LBSL is an autosomal recessive disease and is defined on the basis of a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy. Affected individuals develop slowly progressive cerebellar ataxia, spasticity, and dorsal column dysfunction, sometimes with a mild cognitive deficit or decline. Belongs to the class-II aminoacyl-tRNA synthetase family.
Protein type: EC 6.1.1.12; Ligase; Mitochondrial; Translation
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: mitochondrial matrix; mitochondrion; nucleus
Molecular Function: aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; ATP binding; protein binding; protein homodimerization activity; tRNA binding
Biological Process: tRNA aminoacylation; tRNA aminoacylation for protein translation
Disease: Leukoencephalopathy With Brainstem And Spinal Cord Involvement And Lactate Elevation
Research Articles on DARS2
1. Mutations with mild effects on solubility occur in patients as allelic combinations whereas those with strong effects on solubility or on aminoacylation are necessarily associated with a partially functional allele.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
