Product Name
CTRC, Recombinant Protein
Full Product Name
Recombinant Human CTRC Protein
Product Synonym Names
CLCR; Chymotrypsin-C; Caldecrin
Product Gene Name
CTRC recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
CGVPSFPPNL SARVVGGEDA RPHSWPWQIS LQYLKNDTWR HTCGGTLIAS NFVLTAAHCI SNTRTYRVAV GKNNLEVEDE EGSLFVGVDT IHVHKRWNAL LLRNDIALIK LAEHVELSDT IQVACLPEKD SLLPKDYPCY VTGWGRLWTN GPIADKLQQG LQPVVDHATC SRIDWWGFRV KKTMVCAGGD GVISACNGDS GGPLNCQLEN GSWEVFGIVS FGSRRGCNTR KKPVVYTRVS AYIDWINEKM QLVDHHHHHH
3D Structure
ModBase 3D Structure for Q99895
Purity/Purification
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 muM filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Endotoxin
Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
Directions for Use
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Preparation and Storage
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
Other Notes
Small volumes of CTRC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTRC recombinant protein
Recombinant Human CTRC Protein is produced by our Mammalian expression system and the target gene encoding Cys17-Leu268 is expressed with a 6His tag at the C-terminus.
Applications Tested/Suitable for CTRC recombinant protein
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
NCBI/Uniprot data below describe general gene information for CTRC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_009203.2
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NCBI GenBank Nucleotide #
NM_007272.2
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UniProt Primary Accession #
Q99895
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UniProt Secondary Accession #
O00765; Q9NUH5; A8K082[Other Products]
UniProt Related Accession #
Q99895[Other Products]
Molecular Weight
29,484 Da
NCBI Official Full Name
chymotrypsin-C preproprotein
NCBI Official Synonym Full Names
chymotrypsin C
NCBI Official Symbol
CTRC??[Similar Products]
NCBI Official Synonym Symbols
CLCR; ELA4
??[Similar Products]
NCBI Protein Information
chymotrypsin-C
UniProt Protein Name
Chymotrypsin-C
UniProt Synonym Protein Names
Caldecrin
Protein Family
Chymotrypsin
UniProt Gene Name
CTRC??[Similar Products]
UniProt Synonym Gene Names
CLCR??[Similar Products]
UniProt Entry Name
CTRC_HUMAN
NCBI Summary for CTRC
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CTRC
CTRC: Has chymotrypsin-type protease activity and hypocalcemic activity. Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: EC 3.4.21.2; Protease
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: extracellular region
Molecular Function: peptidase activity; protein binding
Biological Process: cobalamin metabolic process
Disease: Pancreatitis, Hereditary
Research Articles on CTRC
1. Human anionic trypsinogen is controlled by CTRC in a manner that individual natural mutations are unlikely to increase stability enough to promote intra-pancreatic activation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
