Full Product Name
mTLR3 Polyclonal Antibody
Product Gene Name
anti-mTLR3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99MB1
Species Reactivity
Mouse (Predicted Reactivity: Human
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200μl (lot specific)
Immunogen
A partial recombinant mTLR3 protein (amino acids 180-400) was used as the immunogen for this antibody.
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
Other Notes
Small volumes of anti-mTLR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-mTLR3 antibody
TLR
Applications Tested/Suitable for anti-mTLR3 antibody
Western Blot (WB)
Application Notes for anti-mTLR3 antibody
Western Blot: 2-4 μg
Western Blot (WB) of anti-mTLR3 antibody
Expression analysis of mTLR3. Anti- mTLR3 antibody (11-3025) was used at 2 μg/ml on EL-4.
NCBI/Uniprot data below describe general gene information for mTLR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_569054.2
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NCBI GenBank Nucleotide #
NM_126166.4
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UniProt Primary Accession #
Q99MB1
[Other Products]
UniProt Secondary Accession #
Q91ZM4[Other Products]
UniProt Related Accession #
Q99MB1[Other Products]
Molecular Weight
103,671 Da
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll-like receptor 3
NCBI Official Symbol
Tlr3??[Similar Products]
NCBI Official Synonym Symbols
AI957183
??[Similar Products]
NCBI Protein Information
toll-like receptor 3
UniProt Protein Name
Toll-like receptor 3
UniProt Synonym Protein Names
CD_antigen: CD283
UniProt Gene Name
Tlr3??[Similar Products]
UniProt Entry Name
TLR3_MOUSE
UniProt Comments for mTLR3
TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: cell surface; membrane; lysosomal membrane; endoplasmic reticulum; cytoplasm; integral to membrane; intracellular; endosome
Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; RNA binding; double-stranded RNA binding; receptor activity
Biological Process: positive regulation of interleukin-12 production; microglial cell activation; positive regulation of JNK cascade; defense response; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; inflammatory response; defense response to virus; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; MyD88-independent toll-like receptor signaling pathway; response to virus; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; microglial cell activation during immune response; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process
Research Articles on mTLR3
1. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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