Anti -DEFA5 (Defensin-5, Defensin, alpha 5, HD5(20-94), DEF5)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 8; NC_000008.10 (6912829..6914259, complement). Location: 8p23.1

Polyclonal

IgG

Rabbit

Recognizes human DEFA5.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.4.

0.5 mg/mL (lot specific)

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-DEFA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.

Antibodies; Abs to Defensin

Suitable for use in Western Blot (WB). Other applications have not been tested.

Optimal dilutions to be determined by the researcher.

Western Blot analysis of DEFA5 expression in transfected 293T cel line using MBS644032.
Lane 1: DEFA5 transfected lysate (10.1 kD)
Lane 2: Non-transfected lysate.

10,071 Da[Similar Products]

defensin, alpha 5, Paneth cell-specific

defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein

Defensin-5

DEF5??[Similar Products]

DEF5_HUMAN

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Jul 2008]

DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

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