Full Product Name
Human DEFA5 Polyclonal Antibody
Product Synonym Names
DEF5; Defensin; alpha 5; HD5(20-94)
Product Gene Name
anti-DEFA5 antibody
[Similar Products]
Matching Pairs
Antibody: DEFA5 (MBS2898361)
Antigen: Defensin-5 (MBS2889335)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q01523
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human DEFA5 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-DEFA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DEFA5 antibody
Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for DEFA5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_066290.1
[Other Products]
NCBI GenBank Nucleotide #
NP_066290.1
[Other Products]
UniProt Primary Accession #
Q01523
[Other Products]
UniProt Related Accession #
Q01523[Other Products]
NCBI Official Full Name
defensin-5 preproprotein
NCBI Official Synonym Full Names
defensin alpha 5
NCBI Official Symbol
DEFA5??[Similar Products]
NCBI Official Synonym Symbols
DEF5; HD-5
??[Similar Products]
NCBI Protein Information
defensin-5
UniProt Protein Name
Defensin-5
UniProt Synonym Protein Names
Defensin, alpha 5; HD5(20-94)
UniProt Gene Name
DEFA5??[Similar Products]
UniProt Synonym Gene Names
DEF5??[Similar Products]
UniProt Entry Name
DEF5_HUMAN
NCBI Summary for DEFA5
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
UniProt Comments for DEFA5
DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region
Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
Research Articles on DEFA5
1. this study demonstrates that age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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