LCCS3; PIPKIg_v4; PIP5Kgamma; PIP5K-GAMMA

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

0.9mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-PIP5K1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4, 5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000
IHC: 1:25-1:100

Western Blot analysis of A431 and hela cell using PIP5K1C Polyclonal Antibody at dilution of 1:500

Immunohistochemistry of paraffin-embedded Human liver cancer using PIP5K1C Polyclonal Antibody at dilution of 1:25

Immunohistochemistry of paraffin-embedded Human brain using PIP5K1C Polyclonal Antibody at dilution of 1:25

70,214 Da

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; diphosphoinositide kinase; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

KIAA0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma??[Similar Products]

PI51C_HUMAN

This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]

PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.

Protein type: Motility/polarity/chemotaxis; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: focal adhesion; endomembrane system; uropod; nucleus; cytosol; phagocytic cup

Molecular Function: protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding

Biological Process: neutrophil chemotaxis; axon guidance; cell-cell adhesion; synaptic vesicle exocytosis; cytoskeletal anchoring; phosphoinositide phosphorylation; phospholipid metabolic process; synaptic vesicle endocytosis; phosphatidylinositol biosynthetic process; actin cytoskeleton organization and biogenesis; phagocytosis

Disease: Lethal Congenital Contracture Syndrome 3

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