Product Name
PIP5K1C, Polyclonal Antibody
Full Product Name
PIP5K1C Antibody - C-terminal region
Product Gene Name
anti-PIP5K1C antibody
[Similar Products]
Product Synonym Gene Name
LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60331
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 16% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human PIP5K1C
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PIP5K1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PIP5K1C antibody
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Product Categories/Family for anti-PIP5K1C antibody
Polyclonal; Protein Kinases; Cell Adhesion; Growth Factors & Hormones; Cell Biology; Developmental Biology; Immunology; Mitochondria; Membrane & Traffic; DNA/RNA/Protein Interactions;
Applications Tested/Suitable for anti-PIP5K1C antibody
Western Blot (WB)
Western Blot (WB) of anti-PIP5K1C antibody
Host: Rabbit
Target Name: PIP5K1C
Sample Tissue: HepG2 Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for PIP5K1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001182662.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001195733.1
[Other Products]
UniProt Primary Accession #
O60331
[Other Products]
UniProt Related Accession #
O60331[Other Products]
NCBI Official Full Name
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
NCBI Official Symbol
PIP5K1C??[Similar Products]
NCBI Official Synonym Symbols
LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma
??[Similar Products]
NCBI Protein Information
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Protein Name
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Synonym Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type I gamma
Protein Family
Phosphatidylinositol 4-phosphate 5-kinase
UniProt Gene Name
PIP5K1C??[Similar Products]
UniProt Synonym Gene Names
KIAA0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma??[Similar Products]
UniProt Entry Name
PI51C_HUMAN
NCBI Summary for PIP5K1C
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]
UniProt Comments for PIP5K1C
PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis; EC 2.7.1.68; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: focal adhesion; endomembrane system; uropod; cytosol; nucleus; phagocytic cup
Molecular Function: protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding
Biological Process: neutrophil chemotaxis; axon guidance; synaptic vesicle exocytosis; cell-cell adhesion; phosphoinositide phosphorylation; cytoskeletal anchoring; phospholipid metabolic process; synaptic vesicle endocytosis; phosphatidylinositol biosynthetic process; actin cytoskeleton organization and biogenesis; phagocytosis
Disease: Lethal Congenital Contracture Syndrome 3
Research Articles on PIP5K1C
1. The Btk-dependent PIP5K1gamma lipid kinase activation by Fas counteracts FasL-induced cell death.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
