Product Name
PIP5K1C, Polyclonal Antibody
Full Product Name
PIP5K1C Polyclonal Antibody
Product Synonym Names
LCCS3; PIPKIg_v4; PIP5Kgamma; PIP5K-GAMMA
Product Gene Name
anti-PIP5K1C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
0.6mg/mL (lot specific)
Immunogen
Synthetic peptide of human PIP5K1C
Calculated Molecular Weight: 73kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-PIP5K1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PIP5K1C antibody
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4, 5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Applications Tested/Suitable for anti-PIP5K1C antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PIP5K1C antibody
WB: 1:200-1:1000
Western Blot (WB) of anti-PIP5K1C antibody
Western Blot analysis of A431 and hela cell,Mouse brain tissue using PIP5K1C Polyclonal Antibody at dilution of 1:500
NCBI/Uniprot data below describe general gene information for PIP5K1C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001287778.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001300849.1
[Other Products]
UniProt Secondary Accession #
Q7LE07; B7Z9E7; C6GIJ7; C6GIJ8[Other Products]
UniProt Related Accession #
O60331[Other Products]
Molecular Weight
70,214 Da
NCBI Official Full Name
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 3
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
NCBI Official Symbol
PIP5K1C??[Similar Products]
NCBI Official Synonym Symbols
LCCS3; PIP5Kgamma; PIP5K-GAMMA; PIP5K1-gamma
??[Similar Products]
NCBI Protein Information
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; diphosphoinositide kinase; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase
UniProt Protein Name
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Synonym Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PIP5KIgamma
Protein Family
Phosphatidylinositol 4-phosphate 5-kinase
UniProt Gene Name
PIP5K1C??[Similar Products]
UniProt Synonym Gene Names
KIAA0589; PIP5K1-gamma; PtdIns(4)P-5-kinase 1 gamma; PIP5KIgamma??[Similar Products]
UniProt Entry Name
PI51C_HUMAN
NCBI Summary for PIP5K1C
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]
UniProt Comments for PIP5K1C
PIP5K1C: a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.
Protein type: EC 2.7.1.68; Motility/polarity/chemotaxis; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: focal adhesion; endomembrane system; uropod; cytosol; nucleus; phagocytic cup
Molecular Function: protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding
Biological Process: axon guidance; neutrophil chemotaxis; synaptic vesicle exocytosis; cell-cell adhesion; cytoskeletal anchoring; phosphoinositide phosphorylation; phospholipid metabolic process; synaptic vesicle endocytosis; phosphatidylinositol biosynthetic process; actin cytoskeleton organization and biogenesis; phagocytosis
Disease: Lethal Congenital Contracture Syndrome 3
Research Articles on PIP5K1C
1. PIPKIgamma binds to the cryptic polo-box domain of PLK4 and reduces the kinase activity of PLK4.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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