Product Name
Frizzled-4 (fzd4), Recombinant Protein
Full Product Name
Recombinant Xenopus laevis Frizzled-4 (fzd4)
Product Gene Name
fzd4 recombinant protein
[Similar Products]
Product Synonym Gene Name
fz4[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
23-523aa; full length protein
Sequence
FGEEEERSCD PIRITMCQNL GYNVTKMPNL VGHELQADAE LQLTTFTPLI QYGCSSQLQF FLCSVYVPMC TEKINIPIGP CGGMCLSVKR RCEPVLKEFG FAWPESLNCS KFPPQNDHNH MCMEGPGDDE VPAHSKTPVL PGEDCNSFGP NSDQYTWVKR SMNCVLKCGY DSGLYNRLSK EFTDIWMAVW ASLCFISTAF TVLTFLIDSS RFCYPERPII FLSMCYNIYS IAYIVRLTVG RERISCDFEE AAEPVLIQEG LKNTGCAIIF LLMYFFGMAS SIWWVILTLT WFLAAGLKWG HEAIEMHSSY FHIAAWAIPA VKTIVILIMR LVDADELTGL CYVGNQNIDA LTGFVVAPLF TYLVIGTLFI AAGLVALFKI RSNLQKDGTK TDKLERLMVK IGVFSVLYTV PATCVIACYF YEVSNWNVFR YTADDSNMAV EMLNIFMSLL VGITSGMWIW SAKTLHTWQK CTNRLVNSGK VKRKKRVDGW VKPGKGNETV V
3D Structure
ModBase 3D Structure for Q9PT62
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Xenopus laevis (African clawed frog)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of fzd4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for fzd4 recombinant protein
Transmembrane Protein
Application Notes for fzd4 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for fzd4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001083922.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001090453.1
[Other Products]
UniProt Primary Accession #
Q9PT62
[Other Products]
UniProt Related Accession #
Q9PT62[Other Products]
Molecular Weight
58,741 Da
NCBI Official Full Name
frizzled-4
NCBI Official Synonym Full Names
frizzled class receptor 4
NCBI Official Symbol
fzd4??[Similar Products]
NCBI Official Synonym Symbols
fz4; frizzled4
??[Similar Products]
NCBI Protein Information
frizzled-4
UniProt Protein Name
Frizzled-4
UniProt Gene Name
fzd4??[Similar Products]
UniProt Synonym Gene Names
fz4; Fz-4; Xfz4??[Similar Products]
UniProt Entry Name
FZD4_XENLA
UniProt Comments for fzd4
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt5A.
Research Articles on fzd4
1. A splice variant of the Frizzled-4 receptor modulates Wnt signalling in a dose-dependent, biphasic manner.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
