Product Name
Chymotrypsin (CTRC), Monoclonal Antibody
Full Product Name
Chymotrypsin antibody
Product Synonym Names
Monoclonal Chymotrypsin; Anti-Chymotrypsin
Product Gene Name
anti-CTRC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99895
Species Reactivity
Human chymotrypsin
Form/Format
Supplied as a liquid in PBS, pH 7.4.
Biological Significance
Chymotrypsin is a digestive enzyme that can perform proteolysis. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a tyrosine, tryptophan, or phenylalanine. These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. The hydrophobic and shape complementarity between the peptide substrate P1 sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine at the P1 position.
Immunogen
Chymotrypsin antibody was raised in mouse using purified human pancreatic chymotrypsin as the immunogen.
Preparation and Storage
Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of anti-CTRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTRC antibody
Mouse monoclonal Chymotrypsin antibody
Product Categories/Family for anti-CTRC antibody
Proteases, Inhibitors, & Enzymes
Applications Tested/Suitable for anti-CTRC antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CTRC antibody
ELISA: 1:204,800
NCBI/Uniprot data below describe general gene information for CTRC. It may not necessarily be applicable to this product.
NCBI Accession #
CAA74031.1
[Other Products]
UniProt Primary Accession #
Q99895
[Other Products]
UniProt Secondary Accession #
O00765; Q9NUH5; A8K082[Other Products]
Molecular Weight
29,484 Da[Similar Products]
NCBI Official Full Name
chymotrypsin, partial
UniProt Protein Name
Chymotrypsin-C
UniProt Synonym Protein Names
Caldecrin
Protein Family
Chymotrypsin
UniProt Gene Name
CTRC??[Similar Products]
UniProt Synonym Gene Names
CLCR??[Similar Products]
UniProt Entry Name
CTRC_HUMAN
UniProt Comments for CTRC
CTRC: Has chymotrypsin-type protease activity and hypocalcemic activity. Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: Protease; EC 3.4.21.2
Chromosomal Location of Human Ortholog: 1p36.21
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: proteolysis
Disease: Pancreatitis, Hereditary
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
