Product Name
Zinc finger protein PLAG1 (Plag1), Recombinant Protein
Full Product Name
Recombinant Mouse Zinc finger protein PLAG1 (Plag1)
Product Gene Name
Plag1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Plag1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-499aa, full length protein
Sequence
MATVIPGDLS EVRDTQKAPS GKRKRGESKP RKNFPCQLCD KAFNSVEKLK VHSFSHTGER PYKCTHQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHDPNKET FKCEECGKSY NTKLGFKRHL ALHAATSGDL TCKVCLQNFE STGVLLEHLK SHAGKSSGGV KEKKHQCEHC ERRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL LKVKTEPVDF LDPFTCNMSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS SGSAHQMITT LPLGMTCPID MDAVHPSHHL AFKCPFSSTS YAISIPEKEQ PLKGEIESYL MELQGGAPSS SQDSPASSSK LGLEPQSGSP DDGAGDLSLS KSSISISDPL STPALDFSQL FNFIPLNGPP YNPLSVGSLG MSYSQEEAHS SVSQLPTQTQ DLQDPANTVG LSSLHSLSAA FTSSLSSSTT LPRFHQAFQ
3D Structure
ModBase 3D Structure for Q9QYE0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Plag1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Plag1 recombinant protein
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Plag1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064353.2
[Other Products]
NCBI GenBank Nucleotide #
NM_019969.3
[Other Products]
UniProt Primary Accession #
Q9QYE0
[Other Products]
UniProt Secondary Accession #
Q3UXC0; B1AXC4[Other Products]
UniProt Related Accession #
Q9QYE0[Other Products]
Molecular Weight
55,579 Da
NCBI Official Full Name
zinc finger protein PLAG1
NCBI Official Synonym Full Names
pleiomorphic adenoma gene 1
NCBI Official Symbol
Plag1??[Similar Products]
NCBI Protein Information
zinc finger protein PLAG1
UniProt Protein Name
Zinc finger protein PLAG1
UniProt Synonym Protein Names
Pleiomorphic adenoma gene 1 protein
Protein Family
Zinc finger protein
UniProt Gene Name
Plag1??[Similar Products]
UniProt Comments for Plag1
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11.
Research Articles on Plag1
1. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
