For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of CAVIN1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide

Immunohistochemistry (IHC), Western Blot (WB)

43kDa

caveolae associated 1

caveolae-associated protein 1; polymerase I and transcript release factor

Polymerase I and transcript release factor

PTRF_MOUSE

PTRF: Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. Defects in PTRF are the cause of congenital generalized lipodystrophy type 4 (CGL4). It is a disorder characterized by the association of congenital generalized lipodystrophy with muscular dystrophy and cardiac anomalies. Congenital generalized lipodystrophy is characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the PTRF/SDPR family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription initiation complex

Cellular Component: protein complex; membrane; intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; cytoplasm; plasma membrane; caveola; nucleus

Molecular Function: rRNA binding; rRNA primary transcript binding; RNA binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; transcription termination

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