Full Product Name
Pig ADRB1 Polyclonal Antibody
Product Synonym Names
Beta-1 adrenoreceptor; Beta-1 adrenoceptor
Product Gene Name
anti-ADRB1 antibody
[Similar Products]
Matching Pairs
Antibody: ADRB1 (MBS2894609)
Antigen: Beta-1 adrenergic receptor (MBS2888945)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08588
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human ADRB1 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-ADRB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADRB1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for ADRB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000675.1
[Other Products]
NCBI GenBank Nucleotide #
NP_000675.1
[Other Products]
UniProt Primary Accession #
P08588
[Other Products]
UniProt Related Accession #
P08588[Other Products]
NCBI Official Full Name
beta-1 adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor beta 1
NCBI Official Symbol
ADRB1??[Similar Products]
NCBI Official Synonym Symbols
RHR; B1AR; ADRB1R; BETA1AR
??[Similar Products]
NCBI Protein Information
beta-1 adrenergic receptor
UniProt Protein Name
Beta-1 adrenergic receptor
UniProt Synonym Protein Names
Beta-1 adrenoreceptor
Protein Family
Beta-1 adrenergic receptor
UniProt Gene Name
ADRB1??[Similar Products]
UniProt Synonym Gene Names
ADRB1R; B1AR; Beta-1 adrenoceptor??[Similar Products]
UniProt Entry Name
ADRB1_HUMAN
NCBI Summary for ADRB1
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRB1
ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; drug binding; norepinephrine binding; epinephrine binding; beta-adrenergic receptor activity; alpha-2A adrenergic receptor binding; Ras guanyl-nucleotide exchange factor activity; beta1-adrenergic receptor activity; PDZ domain binding
Biological Process: fear response; diet induced thermogenesis; wound healing; positive regulation of apoptosis; apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; sensory perception of pain; positive regulation of saliva secretion; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; aging; glycogen catabolic process; negative regulation of multicellular organism growth; adenylate cyclase activation; regulation of calcium ion transport; memory; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
Disease: Resting Heart Rate, Variation In
Research Articles on ADRB1
1. No significant associations were observed between ADRB1 (rs1801252, rs1801253) polymorphisms and cardiovascular events or all-cause mortality in Coronary Artery Disease patients.
Precautions
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Disclaimer
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