ADRA2A; adrenergic, alpha-2A-, receptor; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32; OTTHUMP00000058849; alpha-2A-adrenergic receptor; alpha-2AAR subtype C10

For Research Use Only. Not for use in diagnostic procedures.

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of ADRA2A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

48,957 Da

adrenoceptor alpha 2A

alpha-2A adrenergic receptor

Alpha-2A adrenergic receptor

ADRA2R; ADRAR; Alpha-2A adrenoceptor; Alpha-2AAR??[Similar Products]

ADA2A_HUMAN

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: alpha-1B adrenergic receptor binding; alpha-2C adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; heterotrimeric G-protein binding; norepinephrine binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; thioesterase binding

Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; activation of protein kinase B; cell motility; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; glucose homeostasis; intestinal absorption; negative regulation of adenylate cyclase activity; negative regulation of calcium ion transport; negative regulation of calcium ion-dependent exocytosis; negative regulation of cAMP biosynthetic process; negative regulation of insulin secretion; negative regulation of lipid catabolic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of potassium ion transport; Ras protein signal transduction; regulation of insulin secretion; Rho protein signal transduction; signal transduction

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