Product Name
ASIP, cDNA Clone
Full Product Name
ASIP cDNA Clone
Product Gene Name
ASIP cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ASIP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ASIP. It may not necessarily be applicable to this product.
NCBI Accession #
BC104238
[Other Products]
UniProt Secondary Accession #
Q3SXL2[Other Products]
UniProt Related Accession #
P42127[Other Products]
Molecular Weight
14,515 Da
NCBI Official Full Name
Homo sapiens agouti signaling protein, nonagouti homolog (mouse), mRNA
NCBI Official Synonym Full Names
agouti signaling protein
NCBI Official Symbol
ASIP??[Similar Products]
NCBI Official Synonym Symbols
ASP; AGSW; AGTI; AGTIL; SHEP9
??[Similar Products]
NCBI Protein Information
agouti-signaling protein
UniProt Protein Name
Agouti-signaling protein
UniProt Synonym Protein Names
Agouti switch protein
Protein Family
Agouti-signaling protein
UniProt Gene Name
ASIP??[Similar Products]
UniProt Synonym Gene Names
AGTI; AGTIL; ASP; ASP??[Similar Products]
UniProt Entry Name
ASIP_HUMAN
NCBI Summary for ASIP
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include *****-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for ASIP
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2-q12
Cellular Component: extracellular space
Molecular Function: receptor binding
Biological Process: cell-cell signaling; signal transduction
Disease: Skin/hair/eye Pigmentation, Variation In, 9
Research Articles on ASIP
1. Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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