ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody detects endogenous levels of total ADRA2A protein.

Antigen affinity purification

In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

1.1mg/ml (lot specific)

Store at -20 degree C.

Small volumes of anti-ADRA2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:200-1:1000
IHC: 1: 25-100

Gel: 8%SDS-PAGE lysate: 40 |?g, Lane: Human left thymus tissue lysate, Primary antibody: 46306￡¨ADRA2A Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46306(ADRA2A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)

49 kDa

adrenoceptor alpha 2A

alpha-2A adrenergic receptor

Alpha-2A adrenergic receptor

ADRA2R; ADRAR; Alpha-2A adrenoceptor; Alpha-2AAR??[Similar Products]

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

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