Full Product Name
ASIP Antibody
Product Gene Name
anti-ASIP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P42127
Other Notes
Small volumes of anti-ASIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-ASIP antibody
Western blot analysis ASIP using 293 whole cell lysates
NCBI/Uniprot data below describe general gene information for ASIP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001663.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001672.2
[Other Products]
UniProt Primary Accession #
P42127
[Other Products]
UniProt Secondary Accession #
Q3SXL2[Other Products]
UniProt Related Accession #
P42127[Other Products]
Molecular Weight
14,515 Da
NCBI Official Full Name
agouti-signaling protein
NCBI Official Synonym Full Names
agouti signaling protein
NCBI Official Symbol
ASIP??[Similar Products]
NCBI Official Synonym Symbols
ASP; AGSW; AGTI; AGTIL; SHEP9
??[Similar Products]
NCBI Protein Information
agouti-signaling protein
UniProt Protein Name
Agouti-signaling protein
UniProt Synonym Protein Names
Agouti switch protein
Protein Family
Agouti-signaling protein
UniProt Gene Name
ASIP??[Similar Products]
UniProt Synonym Gene Names
AGTI; AGTIL; ASP; ASP??[Similar Products]
NCBI Summary for ASIP
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include *****-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for ASIP
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Research Articles on ASIP
1. ASIP expression is significantly downregulated in human masticatory mucosa during wound healing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
