Product Name
Antithrombin (SERPINC1), Protein
Full Product Name
Mouse Antithrombin
Product Synonym Names
Mouse Antithrombin
Product Gene Name
SERPINC1 protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01008
Purity/Purification
This preparation is >98% pure as determined by SDS-PAGE.
Concentration
3.03 mg/mL determined spectrophotometrically. (lot specific)
Storage Buffer
0.2 M Tris; 0.3 M NaCl; pH 7.4
Procedural Notes
This product is 98% active as determined by Thrombin titration.
Preparation
This prep is prepared from fresh plasma using multi-step chromatographic methods.
Preparation and Storage
At -80 degree C AVOID REPEATED FREEZE THAW CYCLES
Other Notes
Small volumes of SERPINC1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPINC1 protein
Description: Antithrombin is a single chain glycoprotein which acts as the primary inhibitor of thrombin and factor Xa.
Testing Data of SERPINC1 protein
NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
NCBI Accession #
CAA48690.1
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UniProt Primary Accession #
P01008
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UniProt Secondary Accession #
P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0[Other Products]
UniProt Related Accession #
P01008[Other Products]
Molecular Weight
58 kDa[Similar Products]
NCBI Official Full Name
antithrombin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade C (antithrombin), member 1
NCBI Official Symbol
SERPINC1??[Similar Products]
NCBI Official Synonym Symbols
AT3; AT3D; ATIII; THPH7
??[Similar Products]
NCBI Protein Information
antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
UniProt Protein Name
Antithrombin-III
UniProt Synonym Protein Names
Serpin C1
Protein Family
Antithrombin
UniProt Gene Name
SERPINC1??[Similar Products]
UniProt Synonym Gene Names
AT3; ATIII??[Similar Products]
UniProt Entry Name
ANT3_HUMAN
NCBI Summary for SERPINC1
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
UniProt Comments for SERPINC1
SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family.
Protein type: Secreted, signal peptide; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: extracellular space; extracellular region; plasma membrane
Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding
Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient
Disease: Antithrombin Iii Deficiency
Research Articles on SERPINC1
1. prevalence of mutations in a cohort of pediatric patients with venous thromboembolism is reported
Precautions
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Disclaimer
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