Product Name
CDK5RAP2, Polyclonal Antibody
Full Product Name
CDK5RAP2 Antibody
Product Synonym Names
C5P2_HUMAN; CDK5 activator-binding protein C48; CDK5 regulatory subunit associated protein 2; centrosome-associated protein 215; CK5P2; KIAA1633
Product Gene Name
anti-CDK5RAP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SN8
Specificity
CDK5RAP2 Antibody detects endogenous levels of total CDK5RAP2 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5RAP2.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-CDK5RAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CDK5RAP2 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CDK5RAP2 antibody
IHC: 1:50~1:100
ELISA: 1:20000
Immunohistochemistry (IHC) of anti-CDK5RAP2 antibody
Immunohistochemistry analysis of paraffin-embedded human brain, using CDK5RAP2 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for CDK5RAP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001011649.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001011649.2
[Other Products]
UniProt Primary Accession #
Q96SN8
[Other Products]
UniProt Secondary Accession #
Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9[Other Products]
UniProt Related Accession #
Q96SN8[Other Products]
NCBI Official Full Name
CDK5 regulatory subunit-associated protein 2 isoform b
NCBI Official Synonym Full Names
CDK5 regulatory subunit associated protein 2
NCBI Official Symbol
CDK5RAP2??[Similar Products]
NCBI Official Synonym Symbols
C48; MCPH3; Cep215
??[Similar Products]
NCBI Protein Information
CDK5 regulatory subunit-associated protein 2
UniProt Protein Name
CDK5 regulatory subunit-associated protein 2
UniProt Synonym Protein Names
CDK5 activator-binding protein C48; Centrosome-associated protein 215
Protein Family
CDK5 regulatory subunit-associated protein
UniProt Gene Name
CDK5RAP2??[Similar Products]
UniProt Synonym Gene Names
CEP215; KIAA1633??[Similar Products]
NCBI Summary for CDK5RAP2
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for CDK5RAP2
Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes (PubMed:26485573).
Research Articles on CDK5RAP2
1. Data suggest that CDK5RAP2 and CEP170 both interact with microtubule nucleation-promoting region of AKAP350A; CEP68 interacts with distal C-terminal region of AKAP350A; AKAP350A spans the bridge between centrioles. (CDK5RAP2 = CDK5 regulatory subunit associated protein 2; CEP170 = centrosomal protein 170kDa; AKAP350A = A kinase (PRKA) anchor protein (yotiao) 9; CEP68 = centrosomal protein 68kDa)
Precautions
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Disclaimer
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