CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48; Centrosome-associated protein 215; CDK5RAP2; CEP215; KIAA1633

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-CDK5RAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes (PubMed:26485573).

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1:20-1:200
IF: 1:50-1:200

Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7053133 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using MBS7053133 at dilution of 1:100

Immunofluorescent analysis of A549 cells using MBS7053133 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

206,323 Da

CDK5 regulatory subunit associated protein 2

CDK5 regulatory subunit-associated protein 2

CDK5 regulatory subunit-associated protein 2

CEP215; KIAA1633??[Similar Products]

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

CDK5RAP2: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Defects in CDK5RAP2 are the cause of microcephaly primary type 3 (MCPH3). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: cell junction; centrosome; cytoplasm; cytosol; Golgi apparatus; microtubule; pericentriolar material; perinuclear region of cytoplasm; spindle pole

Molecular Function: calmodulin binding; microtubule binding; protein binding; protein kinase binding; tubulin binding

Biological Process: brain development; centriole replication; centrosome organization and biogenesis; chromosome segregation; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; microtubule bundle formation; microtubule cytoskeleton organization and biogenesis; microtubule organizing center organization and biogenesis; negative regulation of centriole replication; neurogenesis; positive regulation of transcription, DNA-dependent

Disease: Microcephaly 3, Primary, Autosomal Recessive

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