Product Name
Chymotrypsin, Human Pancreas (CTRC), Protease
Full Product Name
Chymotrypsin, Human Pancreas
Product Gene Name
CTRC protease
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (15764938..15773153). Location: 1p36.21
3D Structure
ModBase 3D Structure for Q99895
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Lyophilized powder
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Other Notes
Small volumes of CTRC protease vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTRC protease
Increased values of this enzyme and/or its zymogen have been found in patients with cystic fibrosis. Activity: 40-70 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of Suc-Ala-Ala-Pro-Phe-pNA per minute at 25C,
Product Categories/Family for CTRC protease
Elastase, Proteases; Human Chymotrypsin
NCBI/Uniprot data below describe general gene information for CTRC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_009203.2
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NCBI GenBank Nucleotide #
NM_007272.2
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UniProt Primary Accession #
Q99895
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UniProt Secondary Accession #
O00765; Q9NUH5; A8K082[Other Products]
UniProt Related Accession #
Q99895[Other Products]
NCBI Official Full Name
chymotrypsin-C preproprotein
NCBI Official Synonym Full Names
chymotrypsin C (caldecrin)
NCBI Official Symbol
CTRC??[Similar Products]
NCBI Official Synonym Symbols
CLCR; ELA4
??[Similar Products]
NCBI Protein Information
chymotrypsin-C; caldecrin; elastase 4; elastase IV; serum calcium decreasing factor
UniProt Protein Name
Chymotrypsin-C
UniProt Synonym Protein Names
Caldecrin
Protein Family
Chymotrypsin
UniProt Gene Name
CTRC??[Similar Products]
UniProt Synonym Gene Names
CLCR??[Similar Products]
UniProt Entry Name
CTRC_HUMAN
NCBI Summary for CTRC
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CTRC
CTRC: Has chymotrypsin-type protease activity and hypocalcemic activity. Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: Protease; EC 3.4.21.2
Chromosomal Location of Human Ortholog: 1p36.21
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: proteolysis
Disease: Pancreatitis, Hereditary
Research Articles on CTRC
1. Frequencies of CFTR variants p.R75Q, p.I148T, 5T-allele and p.E528E were comparable in patients and controls. We identified 103 CFTR variants, which represents a 2.7-fold risk increase (p<0.0001).
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Disclaimer
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