Product Name
Chymotrypsin, Human Pancreas (CTRC), Protein
Full Product Name
Chymotrypsin, Human Pancreas
Product Synonym Names
Caldecrin; Chymotrypsin C; Chymotrypsin-C; Chymotrypsin C; CLCR; CTRC; CTRC_HUMAN; ELA 4; ELA4; Elastase 4; Elastase IV; Elastase4; Elastase IV; Serum calcium decreasing factor
Product Gene Name
CTRC protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99895
Purity/Purification
>=95%
Form/Format
Lyophilized as a salt-free solid.
Appearance: Lyophilized
Biological Activity
40-70 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of Suc-Ala-Ala-Pro-Phe-pNA/min at 21 degree C, pH 8.0.
Results
40-70 units per mg protein.
Unit Definition
One unit is defined as the amount of enzyme that hydrolyzes one umole of Suc-Ala-Ala-Pro-Phe-pNA/min at 21 degree C, pH 8.0.
Handling
Centrifuge the vial prior to opening.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of CTRC protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTRC protein
Background: Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. Molecular weight of this enzyme is found to be 25 kDa. The pI is 8.75. It selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan, and leucine.
Product Categories/Family for CTRC protein
Proteins and Enzymes; Native Proteins Proteins and Enzymes; Proteases; Trypsin Proteins and Enzymes; Proteins and Enzymes (A-Z)Apoptosis & Related Products; Non-Caspase Proteases; Trypsin
Applications Tested/Suitable for CTRC protein
SDS-PAGE
Testing Data of CTRC protein
NCBI/Uniprot data below describe general gene information for CTRC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_009203.2
[Other Products]
NCBI GenBank Nucleotide #
NM_007272.2
[Other Products]
UniProt Primary Accession #
Q99895
[Other Products]
UniProt Secondary Accession #
O00765; Q9NUH5; A8K082[Other Products]
UniProt Related Accession #
Q99895[Other Products]
Molecular Weight
25.0 kDa
NCBI Official Full Name
chymotrypsin-C preproprotein
NCBI Official Synonym Full Names
chymotrypsin C (caldecrin)
NCBI Official Symbol
CTRC??[Similar Products]
NCBI Official Synonym Symbols
CLCR; ELA4
??[Similar Products]
NCBI Protein Information
chymotrypsin-C
UniProt Protein Name
Chymotrypsin-C
UniProt Synonym Protein Names
Caldecrin
Protein Family
Chymotrypsin
UniProt Gene Name
CTRC??[Similar Products]
UniProt Synonym Gene Names
CLCR??[Similar Products]
UniProt Entry Name
CTRC_HUMAN
NCBI Summary for CTRC
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for CTRC
CTRC: Has chymotrypsin-type protease activity and hypocalcemic activity. Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity. Belongs to the peptidase S1 family. Elastase subfamily.
Protein type: EC 3.4.21.2; Protease
Chromosomal Location of Human Ortholog: 1p36.21
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: proteolysis
Disease: Pancreatitis, Hereditary
Research Articles on CTRC
1. None of the selected 121 pancreatic cancer samples showed a pancreatitis-predisposing mutation in the CTRC gene.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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