Product Name
CRBN, cDNA Clone
Full Product Name
CRBN cDNA Clone
Product Gene Name
CRBN cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccggcg aaggagatca gcaggacgct gcgcacaaca tgggcaacca cctgccgctc ctgcctgaga gtgaggaaga agatgaaatg gaagttgaag accaggatag taaagaagcc aaaaaaccaa acatcataaa ttttgacacc agtctgccga catcacatac atacctaggt gctgatatgg aagaatttca tggcaggact ttgcacgatg acgacagctg tcaggtgatt ccagttcttc cacaagtgat gatgatcctg attcccggac agacattacc tcttcagctt tttcaccctc aagaagtcag tatggtgcgg aatttaattc agaaagatag aacctttgct gttcttgcat acagcaatgt acaggaaagg gaagcacagt ttggaacaac agcagagata tatgcctatc gagaagaaca ggattttgga attgagatag tgaaagtgaa agcaattgga agacaaaggt tcaaagtcct tgagctaaga acacagtcag atggaatcca gcaagctaaa gtgcaaattc ttcccgaatg tgtgttgcct tcaaccatgt ctgcagttca attagaatcc ctcaataagt gccagatatt tccttcaaaa cctgtctcaa gagaagacca atgttcatat aaatggtggc agaaatacca gaggagaaag tttcattgtg caaatctaac ttcatggcct cgctggctgt attccttata tgatgctgag accttaatgg acagaatcaa gaaacagcta cgtgaatggg atgaaaatct aaaagatgat tctcttcctt caaatccaat agatttttct tacagagtag ctgcttgtct tcctattgat gatgtattga gaattcagct ccttaaaatt ggcagtgcta tccagcgact tcgctgtgaa ttagacatta tgaataaatg tacttccctt tgctgtaaac aatgtcaaga aacagaaata acaaccaaaa atgaaatatt cagtttatcc ttatgtgggc cgatggcagc ttatgtgaat cctcatggat atgtgcatga gacacttact gtgtataagg cttgcaactt gaatctgata ggccggcctt ctacagaaca cagctggttt cctgggtatg cctggactgt tgcccagtgt aagatctgtg caagccatat tggatggaag tttacggcca ccaaaaaaga catgtcacct caaaaatttt ggggcttaac gcgatctgct ctgttgccca cgatcccaga cactgaagat gaaataagtc cagacaaagt aatactttgc ttgtaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CRBN cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI Accession #
BC067811
[Other Products]
UniProt Secondary Accession #
Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6[Other Products]
UniProt Related Accession #
Q96SW2[Other Products]
Molecular Weight
50,475 Da
NCBI Official Full Name
Homo sapiens cereblon, mRNA
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
CRBN??[Similar Products]
NCBI Official Synonym Symbols
MRT2; MRT2A
??[Similar Products]
NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
CRBN??[Similar Products]
UniProt Entry Name
CRBN_HUMAN
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p26.2
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination
Disease: Mental Retardation, Autosomal Recessive 2
Research Articles on CRBN
1. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1, but not IKZF3. Small hairpin RNA-mediated knockdown of MYC enhanced the cytotoxicity of IMiDs
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
