Product Name
CRBN, cDNA Clone
Full Product Name
CRBN cDNA Clone
Product Gene Name
CRBN cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccggcg aaggagatca gcaggacgct gcgcacaaca tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt cagatggaat ccagcaagct aaagtgcaaa ttcttcccga atgtgtgttg ccttcaacca tgtctgcagt tcaattagaa tccctcaata agtgccagat atttccttca aaacctgtct caagagaaga ccaatgttca tataaatggt ggcagaaata ccagaagaga aagtttcatt gtgcaaatct aacttcatgg cctcgctggc tgtattcctt atatgatgct gagaccttaa tggacagaat caagaaacag ctacgtgaat gggatgaaaa tctaaaagat gattctcttc cttcaaatcc aatagatttt tcttacagag tagctgcttg tcttcctatt gatgatgtat tgagaattca gctccttaaa attggcagtg ctatccagcg acttcgctgt gaattagaca ttatgaataa atgtacttcc ctttgctgta aacaatgtca agaaacagaa ataacaacca aaaatgaaat attcagttta tccttatgtg ggccgatggc agcttatgtg aatcctcatg gatatgtgca tgagacactt actgtgtata aggcttgcaa cttgaatctg ataggccggc cttctacaga acacagctgg tttcctgggt atgcctggac tgttgcccag tgtaagatct gtgcaagcca tattggatgg aagtttacgg ccaccaaaaa agacatgtca cctcaaaaat tttggggctt aacgcgatct gctctgttgc ccacgatccc agacactgaa gatgaaataa gtccagacaa agtaatactt tgcttgtaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CRBN cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI Accession #
BC017419
[Other Products]
UniProt Secondary Accession #
Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6[Other Products]
UniProt Related Accession #
Q96SW2[Other Products]
Molecular Weight
50,475 Da
NCBI Official Full Name
Homo sapiens cereblon, mRNA
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
CRBN??[Similar Products]
NCBI Official Synonym Symbols
MRT2; MRT2A
??[Similar Products]
NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
CRBN??[Similar Products]
UniProt Entry Name
CRBN_HUMAN
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p26.2
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination
Disease: Mental Retardation, Autosomal Recessive 2
Research Articles on CRBN
1. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1, but not IKZF3. Small hairpin RNA-mediated knockdown of MYC enhanced the cytotoxicity of IMiDs
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Disclaimer
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