Full Product Name
Anti-CRBN Antibody
Product Synonym Names
Protein cereblon
Product Gene Name
anti-CRBN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SW2
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of CRBN protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human CRBN
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CRBN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRBN antibody
Rabbit polyclonal antibody to CRBN
Applications Tested/Suitable for anti-CRBN antibody
Western Blot (WB)
Application Notes for anti-CRBN antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-CRBN antibody
Western blot analysis of CRBN expression in A549 (A), mouse spleen (B), rat brain (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166953.1
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NCBI GenBank Nucleotide #
NM_001173482.1
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UniProt Primary Accession #
Q96SW2
[Other Products]
UniProt Secondary Accession #
Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6[Other Products]
UniProt Related Accession #
Q96SW2[Other Products]
Molecular Weight
50,475 Da
NCBI Official Full Name
protein cereblon isoform 2
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
CRBN??[Similar Products]
NCBI Official Synonym Symbols
MRT2; MRT2A
??[Similar Products]
NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
CRBN??[Similar Products]
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Research Articles on CRBN
1. We sequenced CRBN-thalidomide binding region in 38 thalidomide embryopathy individuals and 136 Brazilians without congenital anomalies, and performed in silico analyses. Eight variants were identified, seven intronic and one in 3'UTR.
Precautions
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Disclaimer
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