Product Name
SLC45A2, cDNA Clone
Full Product Name
SLC45A2 cDNA Clone
Product Gene Name
SLC45A2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggtagca acagtgggca ggctggccgc cacatctata aatccctagc tgatgatggc ccctttgact ctgtggagcc gcctaaaaga cccaccagca gactcatcat gcacagcatg gccatgttcg gaagagagtt ctgctacgcg gtggaggcag cgtatgtgac cccagtcctg ctcagcgtag gtctgcccag cagcctgtac agcattgtgt ggttcctcag ccccatcctg ggattcctgc tgcagcccgt ggtcggatcg gccagcgacc actgccggtc caggtggggc cgccggagac cctacatcct caccctggga gtcatgatgc tcgtgggcat ggctctgtac ctcaatgggg ctactgttgt agcagctttg attgctaacc caaggaggaa gctggtttgg gccataagtg tcaccatgat aggtgtcgtt ctctttgatt ttgctgccga cttcattgat gggcccatca aagcctactt atttgatgtc tgctcccatc aggacaagga gaagggcctc cactaccatg ccctcttcac aggttttgga ggtgccctgg gttacctttt gggtgctata gactgggccc atctggagct gggaagactg ttgggtacag aattccaggt catgttcttc ttctctgcat tggtgctcac tttgtgtttt actgttcatc tgtgcagtat ctctgaagcc ccacttacag aggttgcaaa gggcattccc ccacagcaaa cccctcagga ccctccattg tcatcagatg gaatgtacga gtatggttct atcgagaaag ttaaaaatgg ttacgtaaat ccagagctgg caatgcaggg agcaaaaaac aaaaatcatg ctgaacagac tcgcagggca atgacattaa agtcactgct gagagcactg gtgaacatgc ctcctcacta ccgctacctt tgcatcagcc acctcattgg atggacggcc ttcctgtcca acatgctgtt cttcacagat ttcatgggcc agattgtgta ccgcggggat ccctatagtg cacacaactc cacagagttt ctcatctacg aaagaggagt cgaggttgga tgttggggct tctgcatcaa ctccgtgttt tcctcacttt attcttactt tcagaaagtt ttggtatcct acattggatt aaagggtctt tacttcacgg gatatttgct gtttggcctg gggacgggat ttattgggct cttcccgaat gtctactcca ccctggtcct gtgcagcctg tttggtgtaa tgtccagcac cctgtacact gtgcccttta acctcattac tgagtaccac cgcgaggaag aaaaggaggt gtgctgtcat tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC45A2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC45A2. It may not necessarily be applicable to this product.
NCBI Accession #
BC064405
[Other Products]
UniProt Secondary Accession #
Q6P2P0; Q9BTM3[Other Products]
UniProt Related Accession #
Q9UMX9[Other Products]
Molecular Weight
51,200 Da
NCBI Official Full Name
Homo sapiens solute carrier family 45, member 2, mRNA
NCBI Official Synonym Full Names
solute carrier family 45 member 2
NCBI Official Symbol
SLC45A2??[Similar Products]
NCBI Official Synonym Symbols
1A1; AIM1; MATP; OCA4; SHEP5
??[Similar Products]
NCBI Protein Information
membrane-associated transporter protein
UniProt Protein Name
Membrane-associated transporter protein
UniProt Synonym Protein Names
Melanoma antigen AIM1; Protein AIM-1; Solute carrier family 45 member 2
Protein Family
Membrane-associated transporter protein
UniProt Gene Name
SLC45A2??[Similar Products]
UniProt Synonym Gene Names
AIM1; MATP; Protein AIM-1??[Similar Products]
UniProt Entry Name
S45A2_HUMAN
NCBI Summary for SLC45A2
This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for SLC45A2
SLC45A2: Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis. Defects in SLC45A2 are the cause of albinism oculocutaneous type 4 (OCA4). A disorder of pigmentation characterized by reduced biosynthesis of melanin in the skin, hair and eyes. Patients show reduced or lacking pigmentation associated with classic albinism ocular abnormalities, including decreased visual acuity, macular hypoplasia, optic dysplasia, atypical choroidal vessels, and nystagmus. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 5p13.2
Molecular Function: sucrose:hydrogen symporter activity
Biological Process: sucrose transport
Disease: Albinism, Oculocutaneous, Type Iv; Skin/hair/eye Pigmentation, Variation In, 5
Research Articles on SLC45A2
1. We identitified a single missense substitution in SLC45A2 in 13 families with oculocutaneous albinism.
Precautions
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Disclaimer
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