Product Name
60S ribosomal protein L27 (C1D), Recombinant Protein
Full Product Name
Recombinant human 60S ribosomal protein L27 protein
Product Gene Name
C1D recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
GKFMKPGKVV LVLAGRYSGR KAVIVKNIDD GTSDRPYSHA LVAGIDRYPR KVTAAMGKKK IAKRSKIKSF VKVYNYNHLM PTRYSVDIPL DKTVVNKDVF RDPALKRKAR REAKVKFEER YKTGKNKWFF QKLRF
Chromosome Location
Chromosome: 2; NC_000002.11 (68269332..68290159, complement). Location: 2p13-p12
3D Structure
ModBase 3D Structure for Q13901
Purity/Purification
95% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C. For extended storage,conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of C1D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C1D recombinant protein
Belongs to the ribosomal protein L27e family.
Applications Tested/Suitable for C1D recombinant protein
SDS-PAGE, ELISA (EIA), Western Blot (WB)
SDS-PAGE of C1D recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for C1D. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006324.1
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NCBI GenBank Nucleotide #
NM_006333.3
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UniProt Primary Accession #
Q13901
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UniProt Secondary Accession #
Q05D64; A8K336; D6W5F8[Other Products]
UniProt Related Accession #
Q13901[Other Products]
Molecular Weight
42 KD[Similar Products]
NCBI Official Full Name
Homo sapiens C1D nuclear receptor corepressor (C1D), transcript variant 1, mRNA
NCBI Official Synonym Full Names
C1D nuclear receptor corepressor
NCBI Official Symbol
C1D??[Similar Products]
NCBI Official Synonym Symbols
LRP1; hC1D; SUNCOR; SUN-CoR
??[Similar Products]
NCBI Protein Information
nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor
UniProt Protein Name
Nuclear nucleic acid-binding protein C1D
Protein Family
60S ribosomal protein
UniProt Gene Name
C1D??[Similar Products]
UniProt Synonym Gene Names
hC1D??[Similar Products]
UniProt Entry Name
C1D_HUMAN
NCBI Summary for C1D
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
UniProt Comments for C1D
Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB
By similarity. Ref.6 Ref.8 Ref.9 Ref.10
Subunit structure: Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2
By similarity. Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3. Ref.1 Ref.6 Ref.7 Ref.9 Ref.10
Subcellular location: Cytoplasm. Nucleus ? nucleolus. Note: EXOSC10 is required for nucleolar localization. Ref.9 Ref.10
Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. Ref.8
Induction: By gamma-radiation. Ref.6
Post-translational modification: Phosphorylated by PRKDC. Ref.6
Sequence similarities: Belongs to the C1D family.
Research Articles on C1D
1. C1D is associated with the DNA repair complex and may promote repair of ultraviolet irradiation-induced DNA damage.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
